Ph.D. Program in Biomedical Sciences and Oncology

1: Metovic J, Cascardi E, Uccella S, Maragliano R, Querzoli G, Osella-Abate S,
Pittaro A, La Rosa S, Bogina G, Cassoni P, Marchiò C, Sapino A, Castellano I,
Papotti M. Neuroendocrine neoplasms of the breast: diagnostic agreement and
impact on outcome. Virchows Arch. 2022 Dec;481(6):839-846. doi:
10.1007/s00428-022-03426-0. Epub 2022 Oct 15. PMID: 36243799.

2: Metovic J, Borella F, D'Alonzo M, Biglia N, Mangherini L, Tampieri C, Bertero
L, Cassoni P, Castellano I. FOXA1 in Breast Cancer: A Luminal Marker with
Promising Prognostic and Predictive Impact. Cancers (Basel). 2022 Sep
27;14(19):4699. doi: 10.3390/cancers14194699. PMID: 36230619; PMCID: PMC9564251.

3: Metovic J, Napoli F, Osella-Abate S, Bertero L, Tampieri C, Orlando G,
Bianchi M, Carli D, Fagioli F, Volante M, Papotti M. Overexpression of INSM1,
NOTCH1, NEUROD1, and YAP1 genes is associated with adverse clinical outcome in
pediatric neuroblastoma. Virchows Arch. 2022 Dec;481(6):925-933. doi:
10.1007/s00428-022-03406-4. Epub 2022 Sep 19. PMID: 36121500.

4: Metovic J, La Salvia A, Rapa I, Napoli F, Birocco N, Pia Bizzi M, Garcia-
Carbonero R, Ciuffreda L, Scagliotti G, Papotti M, Volante M. Molecular Subtypes
of Extra-pulmonary Neuroendocrine Carcinomas Identified by the Expression of
Neuroendocrine Lineage-Specific Transcription Factors. Endocr Pathol. 2022
Sep;33(3):388-399. doi: 10.1007/s12022-022-09722-4. Epub 2022 May 24. PMID:
35608806; PMCID: PMC9420091.

5: Gambella A, Barreca A, Osella-Abate S, Bottasso E, Giarin MM, Papotti M,
Biancone L, Metovic J, Collemi G, Cassoni P, Bertero L. Caveolin-1 in Kidney
Chronic Antibody-Mediated Rejection: An Integrated Immunohistochemical and
Transcriptomic Analysis Based on the Banff Human Organ Transplant (B-HOT) Gene
Panel. Biomedicines. 2021 Sep 26;9(10):1318. doi: 10.3390/biomedicines9101318.
PMID: 34680435; PMCID: PMC8533527.

6: Bulloni M, Sandrini G, Stacchiotti I, Barberis M, Calabrese F, Carvalho L,
Fontanini G, Alì G, Fortarezza F, Hofman P, Hofman V, Kern I, Maiorano E,
Maragliano R, Marchiori D, Metovic J, Papotti M, Pezzuto F, Pisa E, Remmelink M,
Serio G, Marzullo A, Trabucco SMR, Pennella A, De Palma A, Marulli G, Fassina A,
Maffeis V, Nesi G, Naheed S, Rea F, Ottensmeier CH, Sessa F, Uccella S, Pelosi
G, Pattini L. Automated Analysis of Proliferating Cells Spatial Organisation
Predicts Prognosis in Lung Neuroendocrine Neoplasms. Cancers (Basel). 2021 Sep
29;13(19):4875. doi: 10.3390/cancers13194875. PMID: 34638359; PMCID: PMC8508355.

7: Metovic J, Volante M, Righi L, Papotti M. Reply to: Spread Through Air Spaces
(STAS): Can an Artifact Really be Excluded? Am J Surg Pathol. 2021 Oct
1;45(10):1439-1440. doi: 10.1097/PAS.0000000000001791. PMID: 34392270.

8: Falco EC, Daniele L, Metovic J, Bollito E, De Rosa G, Volante M, Papotti M.
Adrenal Rests in the Uro-genital Tract of an Adult Population. Endocr Pathol.
2021 Sep;32(3):375-384. doi: 10.1007/s12022-021-09685-y. Epub 2021 Jun 7. PMID:
34095993; PMCID: PMC8370964.

9: Volante M, Rapa I, Metovic J, Napoli F, Tampieri C, Duregon E, Terzolo M,
Papotti M. Differential Expression Profiles of Cell-to-Matrix-Related Molecules
in Adrenal Cortical Tumors: Diagnostic and Prognostic Implications. J Pers Med.
2021 May 6;11(5):378. doi: 10.3390/jpm11050378. PMID: 34066306; PMCID:
PMC8148197.

10: Metovic J, Castellano I, Marinelli E, Osella-Abate S, Sapino A, Cassoni P,
Papotti M. INSM1 Expression in Breast Neoplasms with Neuroedocrine Features.
Endocr Pathol. 2021 Dec;32(4):452-460. doi: 10.1007/s12022-021-09682-1. Epub
2021 May 19. PMID: 34008122; PMCID: PMC8608773.

11: Metovic J, Bragoni A, Osella-Abate S, Borella F, Benedetto C, Gualano MR,
Olivero E, Scaioli G, Siliquini R, Ferrando PM, Bertero L, Sapino A, Cassoni P,
Castellano I. Clinical Relevance of Tubular Breast Carcinoma: Large
Retrospective Study and Meta-Analysis. Front Oncol. 2021 Apr 29;11:653388. doi:
10.3389/fonc.2021.653388. PMID: 33996576; PMCID: PMC8117349.

12: Metovic J, Bianchi F, Barella M, Papotti M, Pelosi G. SMARCA2 Deficiency
While Preserving SMARCA4 and SMARCB1 in Lung Neuroendocrine Carcinomas. J Thorac
Oncol. 2021 May;16(5):e32-e35. doi: 10.1016/j.jtho.2021.01.1613. PMID: 33896578.

13: Metovic J, Bianchi F, Rossi G, Barella M, Sonzogni A, Harari S, Papotti M,
Pelosi G. Recent advances and current controversies in lung neuroendocrine
neoplasms. Semin Diagn Pathol. 2021 Sep;38(5):90-97. doi:
10.1053/j.semdp.2021.03.002. Epub 2021 Mar 19. PMID: 33810912.

14: Thuillier P, Liberini V, Rampado O, Gallio E, De Santi B, Ceci F, Metovic J,
Papotti M, Volante M, Molinari F, Deandreis D. Diagnostic Value of Conventional
PET Parameters and Radiomic Features Extracted from 18F-FDG-PET/CT for
Histologic Subtype Classification and Characterization of Lung Neuroendocrine
Neoplasms. Biomedicines. 2021 Mar 10;9(3):281. doi: 10.3390/biomedicines9030281.
PMID: 33801987; PMCID: PMC8001140.

15: Metovic J, Abate SO, Borella F, Vissio E, Bertero L, Mariscotti G, Durando
M, Senetta R, Ala A, Benedetto C, Sapino A, Cassoni P, Castellano I. The lobular
neoplasia enigma: management and prognosis in a long follow-up case series.
World J Surg Oncol. 2021 Mar 18;19(1):80. doi: 10.1186/s12957-021-02182-w. PMID:
33736652; PMCID: PMC7976718.

16: Metovic J, Barella M, Bianchi F, Hofman P, Hofman V, Remmelink M, Kern I,
Carvalho L, Pattini L, Sonzogni A, Veronesi G, Harari S, Forest F, Papotti M,
Pelosi G. Morphologic and molecular classification of lung neuroendocrine
neoplasms. Virchows Arch. 2021 Jan;478(1):5-19. doi: 10.1007/s00428-020-03015-z.
Epub 2021 Jan 21. PMID: 33474631; PMCID: PMC7966641.

17: Pelosi G, Bianchi F, Dama E, Metovic J, Barella M, Sonzogni A, Albini A,
Papotti M, Gong Y, Vijayvergia N. A Subset of Large Cell Neuroendocrine
Carcinomas in the Gastroenteropancreatic Tract May Evolve from Pre-existing
Well-Differentiated Neuroendocrine Tumors. Endocr Pathol. 2021
Sep;32(3):396-407. doi: 10.1007/s12022-020-09659-6. Epub 2021 Jan 12. PMID:
33433886.

18: Uccella S, La Rosa S, Metovic J, Marchiori D, Scoazec JY, Volante M, Mete O,
Papotti M. Genomics of High-Grade Neuroendocrine Neoplasms: Well-Differentiated
Neuroendocrine Tumor with High-Grade Features (G3 NET) and Neuroendocrine
Carcinomas (NEC) of Various Anatomic Sites. Endocr Pathol. 2021
Mar;32(1):192-210. doi: 10.1007/s12022-020-09660-z. Epub 2021 Jan 12. PMID:
33433884.

19: Righi L, Righi A, Vatrano S, Rapa I, Listì A, Metovic J, Rocca M, Salone M,
Giovenali P, Sidoni A, Tabbò F, Dei Tos AP, Volante M, Papotti M. Primary lung
adenocarcinoma in three adolescent patients affected by bone sarcomas. Virchows
Arch. 2021 Jun;478(6):1125-1134. doi: 10.1007/s00428-020-02990-7. Epub 2021 Jan
9. PMID: 33420836.

20: Metovic J, Falco EC, Vissio E, Santoro F, Delsedime L, Massa F, Pittaro A,
Osella-Abate S, Cassoni P, Volante M, Righi L, Papotti M. Gross Specimen
Handling Procedures Do Not Impact the Occurrence of Spread Through Air Spaces
(STAS) in Lung Cancer. Am J Surg Pathol. 2021 Feb 1;45(2):215-222. doi:
10.1097/PAS.0000000000001642. PMID: 33323894.

21: Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G,
Papotti M, Pelosi G. Clinical implications of lung neuroendocrine neoplasm
classification. Expert Rev Anticancer Ther. 2021 Apr;21(4):377-387. doi:
10.1080/14737140.2021.1862654. Epub 2020 Dec 24. PMID: 33306420.

22: Maletta F, Falco EC, Gambella A, Metovic J, Papotti M. Noninvasive
Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: From
Echography to Genetic Profile. Tohoku J Exp Med. 2020 Nov;252(3):209-218. doi:
10.1620/tjem.252.209. PMID: 33087681.

23: Poli R, Scatolini M, Grosso E, Maletta F, Gallo M, Liscia D, Nelva A,
Cesario F, Forte G, Metovic J, Volante M, Arvat E, Papotti M. Correction to:
Malignant struma ovarii: next-generation sequencing of six cases revealed Nras,
Braf, and Jak3 mutations. Endocrine. 2020 Dec;70(3):661. doi:
10.1007/s12020-020-02514-y. Erratum for: Endocrine. 2020 Aug 2;: PMID: 33025560.

24: Metovic J, Vignale C, Annaratone L, Osella-Abate S, Maletta F, Rapa I,
Cabutti F, Patriarca S, Gallo M, Nikiforov YE, Volante M, Papotti M. The
Oncocytic Variant of Poorly Differentiated Thyroid Carcinoma Shows a Specific
Immune-Related Gene Expression Profile. J Clin Endocrinol Metab. 2020 Dec
1;105(12):dgaa655. doi: 10.1210/clinem/dgaa655. PMID: 32936917.

25: Poli R, Scatolini M, Grosso E, Maletta F, Gallo M, Liscia D, Nelva A,
Cesario F, Forte G, Metovic J, Volante M, Arvat E, Papotti M. Malignant struma
ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3
mutations. Endocrine. 2021 Jan;71(1):216-224. doi: 10.1007/s12020-020-02438-7.
Epub 2020 Aug 2. Erratum in: Endocrine. 2020 Oct 6;: PMID: 32743766.

26: Salvi M, Molinaro L, Metovic J, Patrono D, Romagnoli R, Papotti M, Molinari
F. Fully automated quantitative assessment of hepatic steatosis in liver
transplants. Comput Biol Med. 2020 Aug;123:103836. doi:
10.1016/j.compbiomed.2020.103836. Epub 2020 May 29. PMID: 32658781.

27: Gambella A, Falco EC, Metovic J, Maletta F, De Angelis C, Maragliano R,
Uccella S, Pacchioni D, Papotti M. Amyloid-Rich Pancreatic Neuroendocrine
Tumors: a Potential Diagnostic Pitfall in Endoscopic Ultrasound-Guided Fine
Needle Aspiration Cytology (EUS-FNAC). Endocr Pathol. 2021 Jun;32(2):318-325.
doi: 10.1007/s12022-020-09625-2. PMID: 32399832.

28: Metovic J, Annaratone L, Linari A, Osella-Abate S, Musuraca C, Veneziano F,
Vignale C, Bertero L, Cassoni P, Ratto N, Comandone A, Grignani G, Piana R,
Papotti M. Prognostic role of PD-L1 and immune-related gene expression profiles
in giant cell tumors of bone. Cancer Immunol Immunother. 2020
Sep;69(9):1905-1916. doi: 10.1007/s00262-020-02594-9. Epub 2020 May 6. PMID:
32377818.

29: Rapa I, Votta A, Giorcelli J, Izzo S, Rigutto A, Metovic J, Napoli F,
Volante M. Proposal of a Panel of Genes Identified by miRNA Profiling as
Candidate Prognostic Biomarkers in Lung Carcinoids. Neuroendocrinology.
2021;111(1-2):115-122. doi: 10.1159/000506401. Epub 2020 Feb 11. PMID: 32040954.

30: Vissio E, Metovic J, Osella-Abate S, Bertero L, Migliaretti G, Borella F,
Benedetto C, Sapino A, Cassoni P, Castellano I. Integration of Ki-67 index into
AJCC 2018 staging provides additional prognostic information in breast tumours
candidate for genomic profiling. Br J Cancer. 2020 Feb;122(3):382-387. doi:
10.1038/s41416-019-0656-6. Epub 2019 Nov 29. PMID: 31780778; PMCID: PMC7000715.

31: Marchiò C, Da Cruz Paula A, Gularte-Merida R, Basili T, Brandes A, da Silva
EM, Silveira C, Ferrando L, Metovic J, Maletta F, Annaratone L, Pareja F, Rubin
BP, Hoschar AP, De Rosa G, La Rosa S, Bongiovanni M, Purgina B, Piana S, Volante
M, Weigelt B, Reis-Filho JS, Papotti M. PAX8-GLIS3 gene fusion is a
pathognomonic genetic alteration of hyalinizing trabecular tumors of the
thyroid. Mod Pathol. 2019 Dec;32(12):1734-1743. doi: 10.1038/s41379-019-0313-x.
Epub 2019 Jul 4. PMID: 31273314; PMCID: PMC7442035.

32: Altinay S, Metovic J, Massa F, Gatti G, Cassoni P, Scagliotti GV, Volante M,
Papotti M. Spread through air spaces (STAS) is a predictor of poor outcome in
atypical carcinoids of the lung. Virchows Arch. 2019 Sep;475(3):325-334. doi:
10.1007/s00428-019-02596-8. Epub 2019 Jun 15. PMID: 31201506.

33: Osella-Abate S, Bertero L, Senetta R, Mariani S, Lisa F, Coppola V, Metovic
J, Pasini B, Puig S S, Fierro MT, Manrique-Silva E, Kumar R, Nagore E, Cassoni
P, Ribero S. <i>TERT</i> Promoter Mutations are Associated with Visceral
Spreading in Melanoma of the Trunk. Cancers (Basel). 2019 Mar 30;11(4):452. doi:
10.3390/cancers11040452. PMID: 30934988; PMCID: PMC6520836.

34: Metovic J, Righi L, Delsedime L, Volante M, Papotti M. Role of
Immunocytochemistry in the Cytological Diagnosis of Pulmonary Tumors. Acta
Cytol. 2020;64(1-2):16-29. doi: 10.1159/000496030. Epub 2019 Mar 15. PMID:
30878997.

35: Metovic J, Gallino C, Zanon E, Bussone R, Russo R, Vissio E, Annaratone L,
Conti L, Papotti M, Cassoni P, Castellano I. Eccrine spiradenoma of the nipple:
Case report, differential diagnosis and literature review. Histol Histopathol.
2019 Aug;34(8):909-915. doi: 10.14670/HH-18-094. Epub 2019 Feb 26. PMID:
30806477.

36: Roxas RBS, Bernardo MCF, Jacoba AP, Lim-Dy J, Alvarado AC, Metovic J,
Annaratone L, Papotti M. Primary Thymic Signet Ring Cell Adenocarcinoma: A
Currently Unrecognized Variant. Int J Surg Pathol. 2019 May;27(3):315-321. doi:
10.1177/1066896918803673. Epub 2018 Sep 27. PMID: 30259765.

37: Rangel N, Fortunati N, Osella-Abate S, Annaratone L, Isella C, Catalano MG,
Rinella L, Metovic J, Boldorini R, Balmativola D, Ferrando P, Marano F, Cassoni
P, Sapino A, Castellano I. FOXA1 and AR in invasive breast cancer: new findings
on their co-expression and impact on prognosis in ER-positive patients. BMC
Cancer. 2018 Jul 3;18(1):703. doi: 10.1186/s12885-018-4624-y. PMID: 29970021;
PMCID: PMC6029370.

38: Mariani S, Bertero L, Coppola V, Saracco G, Arezzo A, Francia Di Celle P,
Metovic J, Marchiò C, Cassoni P. Awareness of mutational artefacts in suboptimal
DNA samples: possible risk for therapeutic choices. Expert Rev Mol Diagn. 2018
May;18(5):467-475. doi: 10.1080/14737159.2018.1468254. Epub 2018 Apr 26. PMID:
29676606.

39: Rangel N, Rondon-Lagos M, Annaratone L, Osella-Abate S, Metovic J, Mano MP,
Bertero L, Cassoni P, Sapino A, Castellano I. The role of the AR/ER ratio in ER-
positive breast cancer patients. Endocr Relat Cancer. 2018 Mar;25(3):163-172.
doi: 10.1530/ERC-17-0417. PMID: 29386247.

40: Bertero L, Massa F, Metovic J, Zanetti R, Castellano I, Ricardi U, Papotti
M, Cassoni P. Eighth Edition of the UICC Classification of Malignant Tumours: an
overview of the changes in the pathological TNM classification criteria-What has
changed and why? Virchows Arch. 2018 Apr;472(4):519-531. doi:
10.1007/s00428-017-2276-y. Epub 2017 Dec 5. PMID: 29209757.

41: Castellano I, Metovic J, Balmativola D, Annaratone L, Rangel N, Vissio E,
Arisio R, Macrì L, Pecchioni C, Sarotto I, Montarolo F, Muscarà F, Marchiò C,
Cassoni P, Kulka J, Sapino A. The impact of malignant nipple discharge cytology
(NDc) in surgical management of breast cancer patients. PLoS One. 2017 Aug
14;12(8):e0182073. doi: 10.1371/journal.pone.0182073. PMID: 28806416; PMCID:
PMC5555566.

 

 

• ESMO Advanced Course on NTRK Gene Fusion - A New Target in Precision Treatment of Cancer. Barcelona, 21-22/10/2019
• Il corso teorico-pratico di patologia endocrina. Milan, 13-14/06/2019
• Advances in mesothelioma research. Turin, 07/05/2019
• Il profilo molecolare del carcinoma polmonare oltre a EGFR: Il ruolo di ALK-ROS1-MET. Turin, 19/09/2018