Ph.D. Program in Biomedical Sciences and Oncology

Contatti

Supervisore

Tesi di dottorato

Systemic inflammation as contributing factor of kidney epithelial tubular dysfunction after traumatic brain injury.

 Extracranial organ dysfunction (EOD) is a typical feature of critically ill patients with traumatic brain injury (TBI). EOD is associated with worse outcome and with systemic inflammation. Previous studies demonstrated that circulating inflammatory mediators may induce renal tubular epithelial cells (TEC) dysfunction and apoptosis, typical features of the so called subclinical acute kidney injury (AKI). The aim of this study was to evaluate subclinical AKI in TBI studying the effects of patients’ plasma on TEC.

 

Attività di ricerca

LIST OF PUBLICATIONS:

 

1) “Intra-tracheal administration of small interfering RNA targeting Fas reduces lung ischemia-reperfusion injury”

Lorenzo Del Sorbo, Andrea Costamagna, Giuseppe Muraca; Giuseppe Rotondo, Federica Civiletti, Barbara Vizio, Ornella Bosco, Erica L Martin Conte, Luisa Delsedime, Enrico Lupia, Vito Fanelli, V Marco Ranieri.

Journal of Heart and Lung Transplantation. October 2014 (under revision)

2) “Enhanced sensitivity to endothelin-1 is mediated by both ET-A and ET-B receptors in an ex vivo model of cerebral vasospasm"

Barbara Assenzio, Erica Leanne Martin, Edgaras Stankevicius, Federica Civiletti, Marco Fontanella, Riccardo Boccaletti, Maurizio Berardino, AnnaTeresa Mazzeo, Alessandro Ducati, Ulf Simonsen, Luciana Mascia

Plos One. 2014 (under revision)

3) “Tryptophan catabolism via kynurenine production in Streptomyces coelicolor: identification of three genes coding for the enzymes of tryptophan to anthranilate pathway."

Francesco Paolo Zummo , Sandra Marineo , Andrea Pace, Federica Civiletti , Anna Giardina , Anna Maria Puglia.

Appl Microbiol Biotechnol. 2012 Jan 11.

 

 

CONFERENCES PRESENTATION AND POSTER ABSTRACTS:

 

1) F. Civiletti, V. Cantaluppi, D. Medica, AT. Mazzeo, B. Assenzio, I. Mastromauro, I. Deambrosis, F. Giaretta, V. Fanelli, L. Mascia.

“Association of traumatic brain injury with extracranial organ dysfunction and systemic inflammation: a potential cause of subclinical acute kidney injury in transplant donors”

51st ERA-EDTA CONGRESS, Amsterdam 31 May - 3 June 2014

2) Serena Bertolini, Alessandra Ghigo, Anna Rita Pisano, Federica Civiletti, Erica Leanne Martin, Fabrizio Facchinetti, Emilio Hirsch.

“PI3Kγ modulates airway smooth muscle contraction, through the regulation of PDE4B enzymatic activity”. Pharmacology 2013 - British Pharmacological Society, London 17-19 December 2013.

3) F. Civiletti, AT. Mazzeo, F. Borelli, V. Fanelli, A. Sollazzo, L. Costa, S. Tosetto, S. Cavallo, M. Berardino, B. Assenzio, EL. Martin, V. Elia, I. Mastromauro, C. Filippini, D. Medica, V. Cantaluppi, L. Mascia.

“Extracranial organ dysfunction after traumatic brain injury: Effect of plasma of brain injured patients On systemic endothelial and kidney epithelial function”

31st National Neurotrauma Symposium, Nashville 3-5 August 2013

4) V. Cantaluppi, F. Civiletti, D. Medica, A.T. Mazzeo, F. Borelli, V. Fanelli, A. Sollazzo, L. Costa, S. Tosetto, S. Cavallo, M. Berardino, B. Assenzio, E.L. Martin, I. Mastromauro, C. Filippini, C. Capisani, L. Biancone, G.P. Segoloni, L. Mascia.

“Danno renale acuto subclinico in pazienti con grave trauma cranico potenziali donatori per trapianto: possibile effetto negativo sulla delayed graft function post trapianto renale”

54° congresso nazionale SIN, Firenze Settembre 2013.

5) AT Mazzeo, F. Borelli, F. Civiletti, V. Fanelli, A Sollazzo, L. Costa, S. Tosetto, S. Cavallo, M Berardino, B Assenzio, EL Martin, I Mastromauro, C Filippini, I Piper, T Howells, A Ducati, L Mascia

“Systemic concentrations of inflammatory mediators are associated with the duration of secondary insults in patients with severe traumatic brain injury”

31st National Neurotrauma Symposium, Nashville 3-5 August 2013

6) A.T. Mazzeo, F. Guaraldi, M. Parasiliti Caprino, A. Berton, G. Mengozzi, M.Lucchiari, F. Borelli, V. Fanelli, F. Civiletti, A. Sollazzo, L. Costa, S. Tosetto, S. Cavallo, M. Berardino, C. Capisani, I. Mastromauro, C. Filippini, A. Ducati, S. Grottoli, E. Ghigo, L. Mascia

“Early detection of antipituitary antibodies and pituitary dysfunction in patients with severe traumatic brain injury”

ESICM, ottobre 2013

7) L. Del Sorbo, G. Muraca, A. Costamagna, G. Rotondo, L. Laudari, F. Civiletti, E. Tonoli, E. Martin, V. Fanelli and V. Ranieri;

“Intratracheal administration of siRNA targeting FAS reduces ischemia-reperfusion-induced lung injury”

32nd International Symposium on Intensive Care and Emergency Medicine

Critical Care 2012, 16 (Suppl 1):P93

8) F. Zummo, S. Marineo, A. Giardina, C. Angelica, F. Civiletti, and A. M. Puglia; "From tryptophan metabolism to peptide antibiotic production in Streptomyces coelicolor" .

28th National Meeting, SIMGBM, Spoleto (Italy), June 11-13 2009.

9) A. Giardina, S. Marineo, F. Zummo, P. Spinelli, F. Civiletti, C. Angelica and A.M. Puglia. “From tryptophan metabolism to Streptomyces coelicolor peptide antibiotic biosynthetic”

VII Congress: Excerpts from DBCS, Palermo (Italy) 17-18 December 2009

 

CONFERENCES, COURSES AND SEMINARS:

 

July, 2, 2014 “Essere giovani protagonisti in H2020: il CV e opportunità di finanziamento attraverso la mobilità internazionale”; Torino.

March, 18, 2014 - “the QUIAGEN GeneRead sample-to-results NGS workflow” ; Torino.

August, 3-5, 2013 - “31st National Neurotrauma Symposium”; Nashville, TN USA.

October, 22-24, 2012 - “ IX Corso di endocrinologia ginecologica e tecniche di riproduzione assistita di i livello”; Palermo.

Otober, 24, 2011– Fifth annual RI.MED Scientific Symposium “Priming the therapeutic pipeline: new strategies for drug discovery”; Palermo

October, 5-8, 2011 – “65° Congresso Nazionale SIAARTI”; Torino.

June, 7, 2011 – “La Real Time PCR: Tecniche di base e applicazioni pratiche”; Orbassano, Torino

May, 12, 2011 – “Essential Protein Purification 2011”; Torino.