Ph.D. Program in Biomedical Sciences and Oncology

Chillemi A, Quarona V, Zito A, Lo Buono N, Azzolino O, Morandi F, Zaccarello G, Mariani V, Pistoia V, Horenstein AL, Malavasi F. “Identification of a murine monoclonal antibody specific for human CD73 with potential to inhibit extracellular production of adenosine”. Cancer Bio-Immunotherapy: XII^th NIBIT Meeting. Siena, Italy (October 9-11, 2014).

Quarona V, Horenstein AL, Chillemi A, Ferri V, Zito A, Zaccarello G, Morandi F, Pistoia V, , Giuliani N, Malavasi F. “The manifacture of tolerance in the human myeloma niche”. Cancer Bio-Immunotherapy: XII^th NIBIT Meeting. Siena, Italy (October 9-11, 2014).

Chillemi A, Quarona V, Zaccarello G, Lo Buono N, Zito A, Mariani V, Arduino C, Franco F, Geuna M, Azzolino O, Musso T, Horenstein AL, Malavasi F. "The role played by CD73 in a natural human CD73 knockout”. 56^th Annual Meeting of the Italian Cancer Society. Ferrara, Italy (September 11-13, 2014).

Malavasi F, Horenstein AL, Quarona V, Ferri V, Chillemi A, Zaccarello G, Morandi F, Pistoia V, Giuliani N. “CD38 and myeloma camouflage: a view from the bone marrow niche”. 56^th Annual Meeting of the Italian Cancer Society. Ferrara, Italy (September 11-13, 2014).

Zaccarello G, Zitella A, Quarona V, Chillemi A, Chiorino G, Bellò M, Tizzani A, Horenstein AL, Bisi G, Malavasi F. “Targeting surface molecules with enzymatic and signaling properties as mAb-immunotherapy for human prostate cancer”. 56^th Annual Meeting of the Italian Cancer Society. Ferrara, Italy (September 11-13, 2014).

Chillemi A, Horenstein AL, Quarona V, Morandi F, Zaccarello G, Zito A, Mariani V, Pistoia V, Malavasi F. “Identification of a murine monoclonal antibody specific for human CD73 and inhibiting extracellular adenosine production generated by the CD38/CD203a/CD73 ectoenzymatic pathway”. Purines 2014: Nucleotides, Nucleosides and Nucleobases, International Conference on Signalling, Drugs and Targets. Bonn, Germany (July 23–27, 2014).

Horenstein AL, Quarona V, Chillemi A, Zaccarello G, Morandi F, Pistoia V, Giuliani N, Malavasi F. “Adenosine and ectoenzymes in myeloma life and survival in the bone marrow niche”. Purines 2014: Nucleotides, Nucleosides and Nucleobases, International Conference on Signalling, Drugs and Targets. Bonn, Germany (July 23–27, 2014).

Horenstein AL, Chillemi A, Morandi F, Zaccarello G, Quarona V, Zito A, Pistoia V, Malavasi F. “Monoclonal antibody ligation of CD73 blocks immunosuppressive adenosine produced by CD38/CD203a/CD73 pathway: potential application in immunotherapy”. IX National Conference of the Italian Society of Immunology, Clinical Immunology and Allergology. Florence, Italy (May 28-31, 2014).

Quarona V, Chillemi A, Roato I, Bolzoni M, Ferri V, Morandi F, Zito A, Zaccarello G, Horenstein AL, Giuliani N, Pistoia V, Malavasi F. “Ectoenzymes and bone marrow: an interchained functional connection”. IX National Conference of the Italian Society of Immunology, Clinical Immunology and Allergology. Florence, Italy (May 28-31, 2014).

Horenstein AL, Morandi F, Morandi B, Carrega P, Chillemi A, Zaccarello G, Mingari MC, Pistoia V, Malavasi F. “Melanoma cells produce adenosine through a CD38/PC-1/CD73 pathway and suppress T cell proliferation”. IX National Conference of the Italian Society of Immunology, Clinical Immunology and Allergology. Florence, Italy (May 28-31, 2014).

Chillemi A, Quarona V, Zaccarello G, Ferracin M, Ghimenti C, Zito A, Massaia M, Horenstein AL, Malavasi F. “CD38 immunotherapy: killing two birds with one stone”. ICI 2013 - 15^th International Congress of Immunology. Milan, Italy (August 22-27, 2013).

Horenstein AL, Chillemi A, Zaccarello G, Quarona V, Zito A, Malavasi F. “CD38/CD203a/CD73 runs in human T lymphocytes a novel adenosinergic loop independent from CD39”. ICI 2013 - 15^th International Congress of Immunology. Milan, Italy (August 22-27, 2013).

Quarona V, Lazzaretti M, Chillemi A, Zito A, Zaccarello G, Horenstein AL,Saccucci F, Pistoia V, Giuliani N, Malavasi F. “Role of ectoenzymes in the interaction between myeloma, bone cells and immune effectors: the potential role of adenosine and the oxytocin/oxytocin receptor”. ICI 2013 - 15^th International Congress of Immunology. Milan, Italy (August 22-27, 2013).

Morandi F, Horenstein AL, Chillemi A, Zaccarello G, Malavasi F, Pistoia V. “Adenosine produced by a CD38-mediated pathway in CD56^bright/CD16^- NK cells inhibits autologous CD4⁺T cell proliferation”. ICI 2013 - 15^th International Congress of Immunology. Milan, Italy (August 22-27, 2013).

Morandi F, Horenstein AL,Morandi B, Carrega P, Chillemi A, Zaccarello G, Mingari MC, Pistoia V, Malavasi F. “Melanoma cells produce adenosine through a CD38/CD73 pathway and suppress CD4⁺ T cell proliferation”. ICI 2013 - 15^th International Congress of Immunology. Milan, Italy (August 22-27, 2013).

Chillemi A, Quarona V, Zaccarello G, Ferracin M, Ghimenti C, Zito A, Massaia M, Horenstein AL, Malavasi F. “CD38 as target molecule at a center stage of the strategy to escape the immune response”. XXV Congress on the ADP-Ribosylation Processes. Pavia, Italy (May 31-June 1, 2013).

Quarona V, Lazzaretti M, Chillemi A, Zito A, Morandi F, Zaccarello G, Horenstein AL,Giuliani N, Malavasi F. “Ectoenzymes shape the environment where myeloma and bone cells interacts and may influence the clinical outcome”. XXV Congress on the ADP-Ribosylation Processes. Pavia, Italy (May 31-June 1, 2013).

Horenstein AL, Chillemi A, Zaccarello G, Morandi F, Quarona V, Zito A, Malavasi F. “A CD38/CD203a/CD73 ectoenzymatic axis independent from CD39 governs in human T lymphocytes a novel adenosinergic loop”. XXV Congress on the ADP-Ribosylation Processes. Pavia, Italy (May 31-June 1, 2013).

Chillemi A, Quarona V, Zaccarello G, Ferracin M, Ghimenti C, Zito A, Massaia M, Horenstein AL, Malavasi F. “Reshaping the myeloma environment to improve anti-CD38-mediated immunotherapy”. IMMUNO 2013 - 10^th International Conference on New Trends in Immunosuppression and Immunotherapy. Barcelona, Spain (March 11-12,2013).

Horenstein AL, Chillemi A, Zaccarello G, Quarona V, Zito A, Malavasi F. “CD38/CD203a/CD73 runs in human T lymphocytes a novel adenosinergic loop independent from CD39”. IMMUNO 2013 - 10^th International Conference on New Trends in Immunosuppression and Immunotherapy. Barcelona, Spain (March 11-12,2013).

Quarona V, Lazzaretti M, Chillemi A, Morandi F, Zito A, Zaccarello G, Horenstein AL,Giuliani N, Malavasi F. “Role of ectoenzymes in the interactions among myeloma, bone cells and immune effectors”. IMMUNO 2013 - 10^th International Conference on New Trends in Immunosuppression and Immunotherapy. Barcelona, Spain (March 11-12,2013).

Zaccarello G, Chillemi A, Fusco R, Brunetti E, Horenstein AL, Omedè P, Audrito V, Deaglio S, Malavasi F. “Cross-talk between CD38 and oxytocin pathway in human plasma cells and myeloma”. 36th FEBS Congress. Turin, Italy (June 25-30, 2011).

Zaccarello G, Chillemi A, Horenstein AL, Omedè P, Deaglio S, Malavasi F. “CD38 and oxytocin receptor in human plasma cells”. 7^th National Congress of the Italian Society for Clinical and Experimental Cytometry. Rimini, Italy (September 23-24, 2010).

Horenstein AL, Sizzano F, Zaccarello G, Chillemi A, Malavasi F. “CD157: a useful marker for the identification and isolation of the human corneal cell subset containing stem cells”. 7^th National Congress of the Italian Society for Clinical and Experimental Cytometry. Rimini, Italy (September 23-24, 2010).

Quarona V, Ferri V, Chillemi A, Bolzoni M, Mancini C, Zaccarello G, Roato I, Morandi F, Marimpietri D, Faccani G, Martella E, Pistoia V, Giuliani N, Horenstein AL, Malavasi F. "Unraveling the contribution of ectoenzymes to myeloma life and survival in the bone marrow niche”. Ann N Y Acad Sci 2014 Jul 21.

Chillemi A, Zaccarello G, Quarona V, Lazzaretti M, Martella E, Giuliani N, Ferracini R, Pistoia V, Horenstein AL, Malavasi F.” CD38 and bone marrow microenvironment”. Front Biosci (Landmark Ed). 2014 Jan 1; 19:152-62.

Brunetti E, Zaccarello G, Chillemi A, Fusco R, Quarona V, Cometa L, Gandione M, Balzola F, Omedé P, Geuna M, Rigardetto R, Horenstein AL, Malavasi F. “Chapter II - Genetics of autism spectrum disorders. Are the different products of CD38 gene related to some aspects of autistic behavior?” In “La complessità dell’autismo”. pp. 43-65. Galati e Gandione eds. Universitas Studiorum pbs, Mantua, October 2013. ISBN 978-88-97683-27-8.

Horenstein AL, Chillemi A, Zaccarello G, Bruzzone S, Quarona V, Zito A, Serra S, Malavasi F. “CD38/CD203a/CD73 ectoenzymatic pathway independent from CD39 runs a novel adenosinergic loop in human T lymphocytes”. OncoImmunology 2013 Sep 1;2(9):e26246.

Chillemi A, Zaccarello G, Quarona V, Ferracin M, Ghimenti C, Massaia M, Horenstein AL, Malavasi F. “Anti-CD38 antibody therapy: windows of opportunity yielded by the functional characteristics of the target molecule”. Mol Med. 2013 Apr 17.

Quarona V, Zaccarello G, Chillemi A, Brunetti E, Singh VK, Ferrero E, Funaro A, Horenstein AL, Malavasi F. "CD38 and CD157: A long journey from activation markers to multifunctional molecules”. Cytometry B Clin Cytom. 2013 Apr 10.

Malavasi F, Deaglio S, Zaccarello G, Horenstein AL, Chillemi A, Audrito V, Serra S, Gandione M, Zitella A, Tizzani A. “The hidden life of NAD⁺-consuming ectoenzymes in the endocrine system”. J Mol Endocrinol. 2010 Jul 21.

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