Rossella Parrotta
- f402-c402 Dottorato in Scienze Biomediche ed Oncologia
- Dottorato: 24° ciclo
- Matricola: 314582
Tesi di dottorato
ANALISI FUNZIONALE E MOLECOLARE DI ISOFORME DI CD157 NEL CONTROLLO DELLA MIGRAZIONE CELLULARE
Tutor: Enza Ferrero
Relatore: Claudia Giachino
Data discussiione tesi: 23/01/2013
Attività di ricerca
- Prognostic role and biological significance of CD157 in malignant pleural mesothelioma.
S. Morone, A. Giacomino, R. Parrotta, N. Lo Buono, I. Rapa, L. Righi, M. Volante, E. Ruffini, S. Demichelis, G. Rovere, S. Novello, E. Ortolan and A. Funaro.
Presented at “53rd annual meeting of the Italian Cancer Society” Turin, Italy, October 19 – 22, 2011
- CD157 expression affects the aggressiveness of epithelial ovarian cancer.
E. Ortolan, N. Lo-Buono, S. Morone, R. Parrotta, R. Arisio, D. Katsaros, G. Chiorino, P. Ostano, I. Rapa, E. Ferrero, M. Volante and A. Funaro.
Presented at “53rd annual meeting of the Italian Cancer Society” Turin, Italy, October 19 – 22, 2011
- Biological role and clinical significance of CD157 in epithelial ovarian cancer.
S. Morone, N. Lo Buono, R. Parrotta, R. Arisio, D. Katsaros, I. Rapa, E. Ferrero, M. Volante, E. Ortolan and A. Funaro
Presented at “17th international meeting of the European Society of Gynaecological Oncology (ESGO)” Milan, Italy, September 11-14, 2011
- Clinical and biological significance of CD157 in malignant pleural mesothelioma.
S. Morone, E. Ortolan, A. Giacomino, R. Parrotta, N. Lo Buono, I. Rapa, L. Righi, M. Volante, E. Ruffini, S. Demichelis, G. Rovere, S. Novello, F. Malavasi and A. Funaro
Presented at “14th World Conference On Lung Cancer” Amsterdam, Olanda, July 3-7, 2011
5. The CD157-integrins partnership orchestrates human monocyte adhesion and transendothelial
migration.
R. Parrotta, N. Lo Buono, S. Morone, A. Giacomino, P. Bovino, G. Nacci, E. Ortolan, E. Ferrero, F.
Malavasi and A. Funaro
Presented at “36th FEBS Congress – Biochemistry for Tomorrow’s Medicine” Torino, Italy, June 25-30,
2011
6. CD157 expression enhances invasiveness of ovarian cancer cells and induces a mesenchymal
phenotype.
N. Lo Buono, M. Scianna, P. Bovino, S. Morone, R. Parrotta, E. Ferrero, C. Giverso, L. Preziosi, F.
Malavasi, A. Funaro and E. Ortolan
Presented at “36th FEBS Congress – Biochemistry for Tomorrow’s Medicine” Torino, Italy, June 25-30,
2011
7. Clinical and biological significance of CD157 in ovarian carcinoma.
A. Funaro, N. Lo-Buono, S. Morone, R. Parrotta, R. Arisio, E. Ferrero, D. Katsaros, I. Rapa, M.
Volante and E. Ortolan
Presented at “36th FEBS Congress – Biochemistry for Tomorrow’s Medicine" Torino, Italy, June 25-30,
2011
Published on FEBS Journal, Volume 278, Issue s1, June 2011, Pages: 5–69 (I.F. 3.129)
8. CD157 is a potential target for inhibition of peritoneal dissemination and invasion and a prognostic
factor in ovarian cancer patients
E. Ortolan, S. Morone, P. Bovino,N. Lo Buono, G. Nacci, R. Parrotta, R. Arisio, D. Katsaros, I. Rapa,
E. Ferrero, G. Migliaretti, M. Volante andA. Funaro.
Presented at “52nd Annual Meeting of the Italian Cancer Society" Roma, Italy, October 4-7, 2010
9. CD157 expression enhances invasiveness of ovarian cancer cells and induces a mesenchymal
phenotype
N. Lo Buono, P. Bovino, S. Morone, R. Parrotta, E. Ferrero, M. Scianna. C. Giverso, L. Preziosi,
F.Malavasi, A. Funaro and E. Ortolan.
Presented at “52nd Annual Meeting of the Italian Cancer Society” Roma, Italy, October 4-7, 2010
10. CD157 and integrins: a dynamic duet orchestrating monocyte migration
R. Parrotta, N. Lo Buono, S. Morone, P. Bovino, G. Nacci, E. Ortolan, A.L. Horenstein, E. Ferrero, F.
Malavasi and A. Funaro.
Presented at “Keystone Symposia Meeting – Innate Immunity: Mechanisms Linking with Adaptive
Immunity” Dublin, Ireland, June 7-12, 2010
11. Functional role and prognostic significance of CD157 in ovarian carcinoma
Erika Ortolan, Simona Morone, Paola Bovino, Nicola Lo-Buono, Rossella Parrotta, Marco Volante,
Dionyssios Katsaros, Riccardo Arisio, Fabio Malavasi and Ada Funaro.
Presented at “51st Annual Meeting of the Italian Cancer Society”
Sesto San Giovanni - Milan, November 23-26, 2009
12. Functional role of CD157 in monocyte migration.
Rossella Parrotta, Nicola Lo Buono, Paola Bovino, Simona Morone, Mariama El Baroudi, Erika
Ortolan, Fabio Malavasi and Ada Funaro.
Presented at “2009 Annual Meeting of the Society for Leukocyte Biology, International Cytokine
Society & International Society for Interferon and Cytokine Research” Lisbon, Portugal, October 18-21,
2009
Published on Cytokine, Volume 48, Issues 1-2, Pages 1-160 (October-November 2009) (I.F. 3.537)
13. CD157 controls peritoneal dissemination and invasion of ovarian carcinoma and is a molecular
predictor of poor clinical outcome.
P. Bovino, E. Ortolan, S. Morone, N. Lo-Buono, R. Parrotta, M. El Baroudi, I. Rapa, M. Volante, E.
Ferrero, D. Katsaros, R. Arisio, F. Malavasi and A. Funaro.
Presented at “16th International Meeting of the European Society of Gynaecological Oncology”
Belgrad, Serbia, October 11-15, 2009
14. Receptor activities of human CD157 in myeloid cells rely on the MAP-kinase signaling cascade.
Nicola Lo Buono, Rossella Parrotta, Paola Bovino, Simona Morone, Erika Ortolan, Fabio Malavasi and
Ada Funaro.
Presented at “41st Annual Meeting of the Society for Leukocyte Biology” Denver, CO November 6-8,
2008
15. Role of human CD157 in ovarian carcinoma cells.
Erika Ortolan, Nicola Lo Buono, Giulia Nacci , Rossella Parrotta , Fabio Malavasi and Ada Funaro
Presented at “49th Annual Meeting of the Italian Cancer Society”
Pordenone, Italy, November 26-29, 2007
16. Isolation of autoantibodies specific for the PDGF receptor alpha from the B cell repertoire of patients
with Systemic Sclerosis.
Giulia Nacci, Nicola Lo Buono, Rossella Parrotta, Erika Ortolan, Gianluca Moroncini, Silvia Svegliati-
Baroni, Enrico V. Avvedimento, Armando Gabrielli, Fabio Malavasi and Ada Funaro.
Presented at “European Bioalpine Convention - Inflammation and autoimmunity brokerage event”
Turin, Italy, November 6-7, 2007
2. Erika Ortolan, Riccardo Arisio, Simona Morone, Paola Bovino, Nicola Lo-Buono, Giulia Nacci, Rossella Parrotta, Dionyssios Katsaros, Ida Rapa, Giuseppe Migliaretti, Enza Ferrero, Marco Volante, Ada Funaro. Functional role and prognostic significance of CD157 in ovarian carcinoma. J Natl Cancer Inst. 2010 Aug 4;102(15):1160-77
3. Lo Buono N.*, Parrotta R.*, Morone S., Bovino P., Nacci G., Ortolan E., Horenstein A. L., Inzhutova A., Ferrero E. and Funaro A. The CD157-integrin partnership controls transendothelial migration and adhesion of human monocyte.
J Biol Chem. 2011 May 27;286(21):18681-91. *These authors contributed equally
1. Lo Buono N., Morone S., Parrotta R., Giacomino A., Ortolan E. and Funaro A. Ectoenzymes in epithelial ovarian carcinoma: potential diagnostic markers and therapeutic target.
In Tech – Open Access Publisher (2011) Ovarian Cancer / Book 1, ISBN 978-953-307-812-0. Rijeka, Croatia
1. October 08-09, 2009
“XXII Italian Meeting on ADP-ribosylation reactions” Novara, Italy
2. October 18-21, 2009
“SLB/ICS/ISICR Cellular and Cytokine Interactions in Health and Disease" Lisbon, Portugal
3. November 8-11, 2009
“XII National Meeting of Human Genetic” – SIGU (Italian Society of Huma Genetics) Torino, Italy
4. June 7-12,2010
Keystone Symposia “Innate Immunity: Mechanisms Linking with Adaptive Immunity” Dublin, Ireland
5. June 25-30, 2011
“36th FEBS Congress – Biochemistry for tomorrow medicine” Torino, Italy
Human Genetics Ph.D Program - Seminars