Professor Lorenzo Del Sorbo
Contacts:
E-mail: lorenzo.delsorbo@unito.it
Telefono: 0116335520 Fax: n/d
Affiliation: Department of Medical Surgical Disciplines
Studies on mediators and receptors involved in sepsis.
Studies on mechanisms and mediators involved in ventilator induced lung injury.
Studies on physiopathology and novel therapeutic strategies of lung transplantation.
Studies on ex-vivo donor lung reconditioning.
Studies on cell therapy in different models of acute lung injury.
Studies on extracorporeal life support strategies for acute respiratory failure, as bridge to lung transplantation and in COPD exacerbation.
Studies on mechanical ventilation strategies during extracorporeal life support for acute respiratory failure, as bridge to lung transplantation and in COPD exacerbation.
Prowess-shock: “Efficacy and safety of drotrecogin alfa (activated) in adult patients with septic shock” (Clinical trials ID: NCT 00604214), sub-investigator.
“Extracorporeal lung assist as bridge to lung transplantation for patients with cystic fibrosis” (Project FFC # 17/2008), Fondazione Ricerca Fibrosi Cistica, Verona, co-investigator.
“Extracorporeal CO2 removal in patients with severe COPD exacerbation failing noninvasive ventilation” (Clinical trials ID: NCT01422681), co-investigator.
“Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock (EUPHRATES)” (Clinical trials ID: NCT01046669), sub-investigator.
“Strategies for Optimal Lung Ventilation in ECMO for ARDS: The SOLVE ARDS Study” (PSI, 2013) (Clinical trials ID: NCT01990456), co-investigator.
Book Chapters
1) Del Sorbo L, Marshall JC. Antibiotic resistance in the Intensive Care Unit. Yearbook of Intensive Care and Emergency Medicine, JL. Vincent Ed. Brussels (Belgium). Springer, 582-591, March 2006.
2) Crimi E, Del Sorbo L, Ranieri VM. Ventilator-Associated Lung Injury. Respiratory System and Artificial Ventilation. A. Gullo, U. Lucangelo, P. Pelosi. Springer, 119-137, January 2008.
3) Del Sorbo L, MartinEL, Ranieri VM. Hypoxemic Respiratory Failure. Chapter 91. Murray and Nadel’s Textbook of Respiratory Medicine, 5th Edition. Saunders Elsevier, 2130-2137, January 2010.
4) Del Sorbo L, Dondi A, Fanelli V and Ranieri VM. Effetti collaterali della ventilazione: ventilator-induced lung injury. Capitolo 15, 1st edition, Antonelli M, Conti G, Ranieri VM Ed. Elsevier. 237-250, September 2012.
5) Del Sorbo L, Ranieri VM. ECCO2R in Obstructive Diseases: Evidence, Indications, Exclusions. Extracorporeal Life Support for Patients with ARDS. Schmidt GA. Springer. Submitted.
Educational modules
1) Munshi L, Goffi A, Del Sorbo L, Fan E. Patient-centred Acute Care Training (PACT) module on extracorporeal life support for adult respiratory failure. European Society of Intensive Care Medicine (ESICM) PACT section on Respiratory Failure. Ed. Chiumello D. Submitted.
Encyclopedia Entries
1) Barberis L, Fanelli V, Del Sorbo L. Pulmonary Mechanics. Encyclopedia of Intensive Care Medicine. Part 16, 1909-1916. Editors: Vincent JL and Hall J. Springer, January 2012.
Conference Publications
1) Del Sorbo L, Zhang H. Toll-like receptor-4 in sepsis: where do we stand? Selected papers of APICE 17 Volume 2, A. Gullo Ed. Trieste (Italy), Springer, APICE November 15th 2002, 15-19, 2002.
2) Del Sorbo L, Crimi E, Zhang H. How hot are the HSP in sepsis? Selected papers of APICE volume 1, A. Gullo Ed. Trieste (Italy), Springer, APICE 14th November 2003, 617-628, 2003.
3) Crimi E, Del Sorbo L, Zhang H. Epithelial lung in host defence and signalling. Selected papers of APICE volume 1, A. Gullo Ed. Trieste (Italy), Springer, APICE 14th November 2003, 593-603, 2003.
4) Del Sorbo L, Dondi A, Fanelli V. Molecular biology for intensivists: signal transduction. 62º Congresso Nazionale SIAARTI – Palermo – 14/17 ottobre 2008. Minerva Anestesiol. 74(Suppl 1-10):363-365, 2008.
5) Costamagna A, Simonetti U, Bonetto C, Del Sorbo L. Non avremo più bisogno della ventilazione meccanica: come ventilare senza ventilatore. 65º Congresso Nazionale SIAARTI – Torino – 5/8 ottobre 2011. Minerva Anestesiol. 77(Suppl 1-10):241-243, 2011.
Pubblications on non peer-reviewed journals
1) Del Sorbo L, Ranieri VM. Respiratory failure and acute respiratory distress syndrome. EJHPPractise. 15:66-69, 2009.
Pubblications on peer-reviewed journals as group collaborator
1) Pappalardo F, Pieri M, Greco T, Patroniti N, Pesenti A, Arcadipane A, Ranieri VM, Gattinoni L, Landoni G, Holzgraefe B, Beutel G, Zangrillo A; Italian ECMOnet (Collaborators: Del Sorbo L). Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score. Intensive Care Med, 39(2): 275-281, 2013.
2) Akoumianaki E1, Maggiore SM, Valenza F, Bellani G, Jubran A, Loring SH, Pelosi P, Talmor D, Grasso S, Chiumello D, Guerín C, Patroniti N, Ranieri VM, Gattinoni L, Nava S, Terragni PP, Pesenti A, Tobin M, Mancebo J, Brochard L. (Collaborators: Del Sorbo L). The Application of Esophageal Pressure Measurement in Patients with Respiratory Failure. Am J Respir Crit Care Med. [Epub ahead of print], 2014.
Pubblications on peer-reviewed journals
1) Biancone L, Cantaluppi V, Boccellino M, Del Sorbo L, Russo S, Albini A, Stamenkovic I, Camussi G. Activation of CD40 favors the growth and vascularization of Kaposi’s sarcoma. Journal of Immunology, 163: 6201-6208, 1999.
2) Biancone L, Cantaluppi V, Boccellino M, Bussolati B, Del Sorbo L, Conaldi PG, Albini A, Toniolo A, Camussi G. Motility induced by human immunodeficiency virus-1 Tat on Kaposi’s sarcoma cells requires platelet-activating factor. Am J Pathol, 155: 1731-1739, 1999.
3) Brizzi MF, Battaglia E, Montrucchio G, Dentelli P, Del Sorbo L, Garbarino G, Pegoraro L, Camussi G. Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism. Circ Res, 84: 785-796, 1999.
4) Del Sorbo L, DeMartino A, Biancone L, Bussolati B, Conaldi PG, Toniolo A, Camussi G. The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat. Eur J Immunol, 29: 1513-1521, 1999.
5) Dentelli P, Del Sorbo L, Rosso A, Molinar A, Garbarino G, Camussi G, Pegoraro L, Brizzi MF. Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation. J Immunol, 163: 2151-2159, 1999.
6) Montrucchio G, Lupia E, Battaglia E, Del Sorbo L, Boccellino M, Biancone L, Emanuelli G, Camussi G. Platelet-activating factor enhances vascular endothelial growth factor-induced endothelial cell motility and neoangiogenesis in a murine matrigel model. Arterioscler Thromb Vasc Biol, 20: 80-88, 2000.
7) Biancone L, Cantaluppi V, Segoloni G, Boccellino M, Del Sorbo L, Conaldi PG, Tjoelker LW, Maruyama S, Cantu E, Stern D, Andres G, Camussi G. Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. Transplantation, 70: 1198-1205, 2000.
8) Del Sorbo L, Arese M, Giraudo E, Tizzani M, Biancone L, Bussolino F, Camussi G. Tat-induced platelet-activating factor synthesis contributes to the angiogenic effect of HIV-1.Tat. Eur J Immunol, 31: 376-383, 2001.
9) Lupia E, Del Sorbo L, Bergerone S, Emanuelli G, Camussi G, Montrucchio G. The membrane attack complex of complement contributes to plasmin-induced synthesis of platelet-activating factor by endothelial cells and neutrophils. Immunology, 109(4):557-63, 2003.
10) Lupia E, Pucci A, Peasso P, Merlo M, Baron P, Zanini C, Del Sorbo L, Rizea-Savu S, Silvestro L, Forni M, Emanuelli G, Camussi G, Montrucchio G. Intra-plaque production of platelet-activating factor correlates with neoangiogenesis in human carotid atherosclerotic lesions. Int J Mol Med, 12(3):327-34, 2003.
11) Lee JH, Del Sorbo L, Khine AA, De Azavedo J, Low DE, Bell D, Uhlig S, Slutsky AS, Zhang H. Modulation of Bacterial Growth by Tumor Necrosis Factor-{alpha} In Vitro and In Vivo. Am J Respir Crit Care Med. 168(12):1462-1470, 2003.
12) Biancone L, Cantaluppi V, Del Sorbo L, Russo S, Tjoelker LW, Camussi G.Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth. Clin Cancer Res, 9(11):4214-20, 2003.
13) Montrucchio G, Bosco O, Del Sorbo L, Fascio Pecetto P, Lupia E, Goffi A, Omede P, Emanuelli G, Camussi G. Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood. Thromb Haemost, 90(5):872-81, 2003.
14) Alloatti G, Levi R, Malan D, Del Sorbo L, Bosco O, Barberis L, Marcantoni A, Bedendi I, Penna C, Azzolino O, Altruda F, Wymann M, Hirsch E, Montrucchio G. Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. Cardiovasc Res, 60(2):242-9, 2003.
15) Lee JH, Del Sorbo L, Uhlig S, Porro GA, Whitehead T, Voglis S, Liu M, Slutsky AS, Zhang H. Intercellular adhesion molecule-1 mediates cellular cross-talk between parenchymal and immune cells after lipopolysaccharide neutralization. J Immunol, 172(1):608-16, 2004.
16) Del Sorbo L, Zhang H. Is there a place for N-acetylcystein in the treatment of septic shock? Critical Care, 8(2):93-95, 2004.
17) Alloatti G, Marcantoni A, Levi R, Gallo MP, Del Sorbo L, Patrucco E, Barberis L, Malan D, Azzolino O, Wymann M, Hirsch E, Montrucchio G. Phosphoinositide 3-kinase gamma controls autonomic regulation of the mouse heart through Gi-independent downregulation of cAMP level. FEBS Lett. 579(1):133-40, 2005.
18) Khine AA, Del Sorbo L, Vaschetto R, Voglis S, Slutsky AS, Downey GP, Zhang H. Human neutrophil peptides induce interleukin-8 production via P2Y6 signaling pathway. Blood, 107(7):2936-42, 2006.
19) Crimi E, Zhang H, Han RNN, Del Sorbo L, Ranieri VM, Slutsky AS.
Hemorrhagic shock and resuscitation increase susceptibility to ventilator-induced lung injury. Am J Respir Crit Care Med. 174(2):178-186, 2006.
20) Lupia E, Bosco O, Bergerone S, Dondi AE, Goffi A, Oliaro E, Cordero M, Del Sorbo L, Trevi G, Montrucchio G. Thrombopoietin contributes to enhanced platelet activation in patients with unstable angina. J Am Coll Cardiol. 48(11):2195-203, 2006.
21) Vaschetto R, Grinstein J, Del Sorbo L, Khine AA, Voglis S, Tullis E, Slutsky AS, Zhang H. Role of human neutrophil peptides in the initial interaction between lung epithelial cells and CD4+ lymphocytes. J Leukoc Biol. 81(4):1022-31, 2007.
22) Del Sorbo L, Ferguson ND. High-frequency oscillation: how high should we go? Crit Care Med. 35(6):1623-4, 2007.
23) Ferreyra GP, Baussano I, Squadrone V, Richiardi L, Marchiaro G, Del Sorbo L, Mascia L, Merletti F, Ranieri VM. Continuous positive airway pressure for treatment of respiratory complications after abdominal surgery: a systematic review and meta-analysis. Ann Surg. 247(4):617-26, 2008.
24) Del Sorbo L, Slutsky AS. Year in Review 2007: Critical Care – respirology. Critical Care. 12(5):231-234, 2009.
25) Del Sorbo L, Thompson BT, Ranieri VM. Post registration trials: Should we? How do we? Crit Care Med. 37(1 Suppl):S154-S158, 2009.
26) Metnitz PG, Metnitz B, Moreno RP, Bauer P, Del Sorbo L, Hoermann C, de Carvalho SA, Ranieri VM; SAPS 3 Investigators. Epidemiology of mechanical ventilation: analysis of the SAPS 3 database. Intensive Care Med. 35(5):816-25, 2009.
27) Del Sorbo L, Fanelli V. Infection versus innate immunity in septic shock. Minerva Anestesiol. 75(9):482-483, 2009.
28) Mascia L, Del Sorbo L. Diagnosis and management of vasospasm. F1000 Med Rep. Apr 29;1, 2009.
29) Terragni PP, Del Sorbo L, Mascia L, Urbino R, Martin EL, Birocco A, Faggiano C, Quintel M, Gattinoni L, Ranieri VM. Tidal Volume Lower than 6 ml/kg Enhances Lung Protection: Role of Extracorporeal Carbon Dioxide Removal. Anesthesiology. 111(4):826-35, 2009.
30) Racca F, Del Sorbo L, Mongini T, Vianello A, Ranieri VM. Respiratory management of acute respiratory failure in neuromuscular diseases. Minerva Anestesiol. 76(1):51-62, 2010.
31) Del Sorbo L, Slutsky AS. Ventilatory support for acute respiratory failure: new and ongoing pathophysiological, diagnostic and therapeutic developments. Curr Opin Crit Care. 16(1):1-7, 2010.
32) Fanelli V, Puntorieri V, Assenzio B, Martin EL, Elia V, Bosco M, Delsedime L, Del Sorbo L, Ferrari A, Italiano S, Ghigo A, Slutsky AS, Hirsch E, Ranieri VM. Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema. Intensive Care Med. 36(11):1935-45, 2010.
33) Ricci D, Boffini M, Del Sorbo L, El Qarra S, Comoglio C, Ribezzo M, Bonato R, Ranieri VM, Rinaldi M.The use of CO2 removal devices in patients awaiting lung transplantation: an initial experience. Transplant Proc. 42(4):1255-8, 2010.
34) Martin EL, Souza DG, Fagundes CT, Amaral FA, Assenzio B, Puntorieri V, Del Sorbo L, Fanelli V, Bosco M, Delsedime L, Pinho JF, Lemos VS, Souto FO, Alves-Filho JC, Cunha FQ, Slutsky AS, Ruckle T, Hirsch E, Teixeira MM, Ranieri VM. Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. Am J Respir Crit Care Med. 182(6):762-73, 2010.
35) Del Sorbo L, Ranieri VM. We do not need mechanical ventilation any more. Crit Care Med. 38(10 Suppl):S555-8, 2010.
36) Del Sorbo L, Slutsky AS. Acute respiratory distress syndrome and multiple organ failure. Curr Opin Crit Care. 17(1):1-6, 2011.
37) Racca F, Bonati M, Del Sorbo L, Berta G, Sequi M, Capello EC, Wolfler A, Salvo I, Bignamini E, Ottonello G, Cutrera R, Biban P, Benini F, Ranieri VM. Invasive and non-invasive long-term mechanical ventilation in Italian children. Minerva Anestesiol. 77(9):892-901, 2011.
38) Ferreyra G, Fanelli V, Del Sorbo L, Ranieri VM. Are guidelines for non-invasive ventilation during weaning still valid? Minerva Anestesiol. 77(9):921-6, 2011.
39) Del Sorbo L, Goffi A, Ranieri VM. Mechanical ventilation during acute lung injury: current recommendations and new concepts. Presse Med. 40(12 Pt 2):e569-83, 2011.
40) Lucangelo U, Del Sorbo L, Boffini M, Ranieri VM. Protective ventilation for lung transplantation. Curr Opin Anaesthesiol. 25(2):170-4, 2012.
41) Racca F, Del Sorbo L, Capello EC, Ranieri VM. Neuromuscular patients as candidates for non invasive ventilation during the weaning process. Minerva Anestesiol. 78(3):391, 2012.
42) Del Sorbo L, Boffini M, Rinaldi M, Ranieri VM. Bridging to lung transplantation by extracorporeal support. Minerva Anestesiol. 78(2):243-50, 2012.
43) Grasso S, Terragni P, Birocco A, Urbino R, Del Sorbo L, Filippini C, Mascia L, Pesenti A, Zangrillo A, Gattinoni L, Ranieri VM. ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure. Intensive Care Med. 38(3):395-403, 2012.
44) Del Sorbo L, Ranieri VM, Keshavjee S. Extracorporeal membrane oxygenation as "bridge" to lung transplantation: what remains in order to make it standard of care? Am J Respir Crit Care Med. 185(7):699-701, 2012.
45) Racca F, Mongini T, Wolfler A, Vianello A, Cutrera R, Del Sorbo L, Capello EC, Gregoretti C, Massa R, De Luca D, Conti G, Tegazzin V, Toscano A, Ranieri VM. Recommendations for anesthesia and perioperative management of patients with neuromuscular disorders. Minerva Anestesiol. 79(4):419-433, 2013.
46) Del Sorbo L, Parotto M, Slutsky AS. Increasing the number of lungs available for transplantation. Minerva Anestesiol. 2013 Nov 26. [Epub ahead of print].
47) Munshi L, Fan E, Del Sorbo L. Prone position during ECMO: A turn of events? Minerva Anestesiol. 2014 Mar;80(3):281-3.
48) Del Sorbo L, Cypel M and Fan E. Extracorporeal life support for adults with severe acute respiratory failure. Lancet Respir Med. 2(2):154-164, 2014.
49) Del Sorbo L, Pisani L, Filippini C, Fanelli V, Fasano L, Terragni P, Dell’Amore A, Urbino R, Mascia L, Evangelista A, Antro C, D’Amato R, Sucre MJ, Simonetti U, Persico P, Nava S and Ranieri VM. Extracorporeal carbon dioxide removal in hypercapnic patients at risk of non-invasive ventilation failure: a matched cohort study with historical control. CCM, in press.
50) Marhong J, Telesnicki T, Munshi L, Del Sorbo L, Detsky M and Fan E. Mechanical Ventilation during Extracorporeal Membrane Oxygenation (ECMO): An International Survey. Annals of the American Thoracic Society, in press.